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課程名稱 |
環境衛生風險評估
Risk Assessment for Environmental Health |
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開課學期 |
100-2 |
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授課對象 |
公共衛生學院 環境衛生研究所 |
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授課教師 |
林嘉明 |
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課號 |
EH7012 |
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課程識別碼 |
844 M1150 |
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班次 |
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學分 |
2 |
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全/半年 |
半年 |
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必/選修 |
必修 |
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上課時間 |
星期三3,4(10:20~12:10) |
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上課地點 |
公衛213 |
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備註 |
限碩士班以上
總人數上限：30人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1002RAEH |
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課程簡介影片 |
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核心能力關聯 |
本課程尚未建立核心能力關連 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
教學目標：本課程透過閱讀、討論、練習等方式,使學生熟悉經由環境與職業暴露化學有害物的健康風險評估，尤其強調方法論與實務應用。
100學年度第2學期(22/02/2012-20/06/2012)環境衛生風險評估課程大綱
課程編號：環境衛生風險評估 844M1150
授課教師：林嘉明 TEL：02-33668103
課程助教：徐仕哲
日期 內容＊ 備註＊
2/22 停課一次
2/29 Introduction & Chemical hazards and risk acceptability
3/07 Exposure, exposure assessment, exposure scenario, and dose
3/14 Exposure dose and dose rates
3/21 Calculation of human dose rate and dose from human and animal studies
3/28 Quantization of response & Calculation of excess risk
4/04 兒童節暨民族掃墓節(放假日)
4/11 Excess risk and dose: Tolerance distribution models
4/18 Midterm examination
4/25 Excess risk and dose: Mechanistic models
5/02 Life time risk estimate for sub-experimental dose range
5/09 Acceptable concentration
5/16 Acceptable concentrations-risk analysis method for non-threshold toxicants
5/23 Acceptable concentrations-safety factor (uncertainty factor) method for threshold toxicants
5/30 Acceptable concentrations (Benchmark dose derived reference
concentration, RfC)-benchmark dose method for threshold toxicants
6/06 Application of software to health risk assessment –Monte Carlo
Simulation
6/13 Plausibility of calculating excess risk; Planning risk assessment; Demonstration of case studies
6/20 Final examination
參考書籍
1. William H. Hallenbeck: Quantitative risk assessment for
environmental and occupational health (2nd Edition), Lewis
Publisher, New York, 1993
2. Jack E. Daugherty: Assessment of chemical exposure, calculation
methods for environmental professionals, Lewis Publishers, New
York, 1998
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課程目標 |
本課程討論化學危害經由環境介質影響人類健康的風險；解釋風險的意義；說明量化風險的過程（危害鑑定、劑量效應分析、暴露評估、風險描述）；並且議論風險量化過程所牽涉的概念、術語、方法學、模式及應用軟體。全程以講述及舉例練習的方式進行。
1.讓學生瞭解風險的技術面意義；
2.讓學生有能力量化暴露劑量；
3.讓學生有能力分析劑量與風險的
關係；
4.讓學生有能力推估及描述終生暴
露低劑量化學物的風險；
5.讓學生有能力推算風險管理上需
要的容許暴露濃度值。
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課程要求 |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
1. William H. Hallenbeck: Quantitative risk assessment for
environmental and occupational health (2nd Edition), Lewis
Publishers, New York, 1993
2. Jack E.Daugherty: Assessment of chemical exposures,
calculation methods for environmental professionals, Lewis
Publishers, New York, 1998
3. Principles for the assessment of risks to human health from exposure to
chemicals, Geneva: World Health Organization, 1999
4. Joseph V. Rodricks: Calculated risks:the toxicity and human health risks of
chemicals in our environment, Cambridge; New York: Cambridge University Press,
2007
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評量方式
(僅供參考) |
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週次 |
日期 |
單元主題 |
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第1週 |
2/22 |
停課一次 |
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第2週 |
2/29 |
Introduction (Risk, health risk assessment, risk management, risk communication, data availability) & Chemical hazards and risk acceptability |
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第3週 |
3/07 |
Exposure, exposure assessment, exposure scenario, and dose |
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第4週 |
3/14 |
Exposure dose and dose rates |
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第5週 |
3/21 |
Calculation of human dose rate and dose from human and animal studies |
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第6週 |
3/28 |
Quantization of response & Calculation of excess risk |
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第7週 |
4/04 |
兒童節暨民族掃墓節(放假日) |
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第8週 |
4/11 |
Excess risk and dose: Tolerance distribution models |
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第9週 |
4/18 |
Excess risk and dose: Mechanistic models |
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第10週 |
4/25 |
Life time risk estimate for sub-experimental dose range(記得帶計算機) |
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第11週 |
5/02 |
Midterm examination(記得帶計算機) |
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第12週 |
5/09 |
Acceptable concentration(記得帶計算機) |
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第13週 |
5/16 |
Acceptable concentrations-risk analysis method for non-threshold toxicants(記得帶計算機) |
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第14週 |
5/23 |
Acceptable concentrations-safety factor (uncertainty factor) method for threshold toxicants(記得帶計算機) |
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第15週 |
5/30 |
Acceptable concentrations (Benchmark dose derived reference concentration, RfC)-benchmark dose method for threshold toxicants(記得帶計算機) |
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第16週 |
6/06 |
Application of software to health risk assessment –Monte Carlo Simulation(記得帶計算機) |
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第17週 |
6/13 |
Plausibility of calculating excess risk; Planning risk assessment; Demonstration of case studies(記得帶計算機) |
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第18週 |
6/20 |
期末考(記得帶計算機) |
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